The Eli Lilly site in Basingstoke has 445 employees and 111 contractors.

Eli Lilly said about 100 people could be eligible for early retirement, some will be offered redeployment but about 300 workers will be made redundant.

The company said the closure is subject to consultation with employees. Andrew Hotchkiss, managing director, said the cuts were caused by “over-capacity”.

Proposing this site closure has been extremely difficult Andrew Hotchkiss managing director

The firm currently manufactures medicines which include Zyprexa, a treatment for severe mental illness and Cialis, a treatment for erectile dysfunction.

The company said the closure plans would not have any impact on patients using the medicines.

Mr Hotchkiss said: “Proposing this site closure has been extremely difficult as we are reluctant to lose the highly-skilled, highly-motivated people who work at the site.

“The announcement today is based on the fact that there is over-capacity in Lilly’s dry product citrate tadalafil
network.

“We have conducted an analysis of our requirements in the dry product area, and whilst these medicines remain important for Lilly, sales forecasts over the next decade indicate that we have too much capacity both now and in the long-term.”

Local MP Maria Miller said she was concerned at the implications for the wider manufacturing base in Basingstoke.

The town is home to a cheap levitra online
number of hi-tech manufacturing industries and Mrs Miller said she was anxious that other firms did not follow Eli Lilly’s lead.

The company has a research facility in Windlesham, Surrey, and a biotechnology manufacturing facility at Speke on Merseyside.

It is being developed by Futura Medical in collaboration with pharmaceutical giant GlaxoSmithKline.

The treatment, called MED2002, is expected to go into clinical trials at the end of 2006.

But the Sexual Tadalafil cialis from india Association said it is buy kamagra uk to await the outcome of these trials to see how effective the product really is.

MED2002, is based on a compound called glyceryl uso continuo tadalafil
(GTN), which has been used to treat angina for the last 40 years. GTN is known to cause dilation of the arteries and increased blood flow.

Any kind of treatment needs to go through a process to find if it is effective or it there are side effects Sexual Dysfunction Association

James Barder, chief executive of Futura Medical, said MED2002 had performed well in early in vitro trials.

The company will now be looking to recruit about 1,500 men to take part in three more clinical studies.

Mr Barder said: “We expect to see this on the market in 2009.”

Physical causes

Mr Barder said the treatment would be non-prescription because GTN “is a well known compound and its buy cialis tadalafil
profile is well characterised”.

But the Sexual Dysfunction Association said it was important to await the outcome of the trials.

A spokesperson said: “The more treatment available the better it will be for any sufferers of erectile dysfunction.

“But obviously any kind of treatment needs to go through a process to find if it is effective or it there are side effects.

“And only after a careful evaluation will we be able to say whether this is a great tool or not.”

Erectile dysfunction is thought to affect about one in every 10 men in the UK.

About 70% of cases are believed to have physical causes, and 30% are because of tadalafil cialis from india factors.

There are currently three oral drugs licensed for the treatment in the UK of erectile dysfunction: Cialis, Levitra and Viagra.

In June, Eli Lilly said it planned to close the factory unless an alternative drugs firm could take over the Basingstoke site and its 555 employees.

No buyer was found and manufacturing will stop at the end of 2007.

Company tadalafil cialis
have said the cuts have been made due to “over capacity” and they hope to relocate some employees to other UK sites.

The company had carried out employee uk can cialis female tadalafil take
on the closure and has said about 100 employees will be eligible for retirement.

US-based Eli Lilly tadalafil cialis from india medicines softtabs tadalafil
Prozac, a treatment for clinical depression and Cialis, a treatment for erectile dysfunction.

Human and animal trials suggest this could offer an online tadalafil kaufen
to current treatments for some patients, the American Society of Gene Therapy heard.

Researchers say gene therapy could be effective far longer than pills used just before sex, improving softtabs tadalafil
.

The human trials involved injections into the penis and some experts queried whether men would choose this option.

New approach

Erectile dysfunction (ED), often referred to as impotence, is thought to affect about one in every 10 men in the UK.

ED collectively means an inability to get a good enough erection to achieve blog cialis purchase trackback url
intercourse, but it varies in severity.

There are many causes, and many effective treatments, including drugs like the three licensed in the UK - Viagra, Cialis and Levitra.

But not all types of ED respond well to medication - for example, ED caused by nerve damage following prostate cancer surgery.

US researchers are hopeful that for these patients, and those who experience condition dysfunction erectile more symptom
with medication, gene therapy may be a good alternative.

Nerve damage

A University of Pittsburgh team, led by Dr Joseph Glorioso, tested an experimental gene therapy in rats with ED caused by nerve damage.

The gene therapy used comprised the herpes simplex virus as a carrier and either a gene called GDNF, or one called neurturin, which both help promote nerve growth.

Rats treated with the gene therapy showed significant recovery and were able to regain normal penile function after four weeks.

This is an exciting field of research because current treatments for men with erectile dysfunction must be used ‘on demand’, thereby reducing the spontaneity of the sexual act Researcher Dr Arnold Melman

Meanwhile, scientists at Wake Forest University, with the help of Dr Arnold Melman from the Albert Einstein College of Medicine, have been conducting the first human study of gene therapy for ED.

Tests on 11 men with ED showed promising results. The treatment was well-tolerated, with few side effects, despite its delivery via an injection into the penis.

Although the primary goal of the study was to determine its safety, it also showed the therapy improved erectile function in some of the men.

Dr Melman said: “This is an exciting field of research because current treatments for men with erectile dysfunction, whether pills or minimally invasive therapies, must be used ‘on demand’, thereby reducing the spontaneity of the sexual act.”

‘Chronic disease’

The Wake Forest therapy works by inserting small pieces of DNA into cells to trigger the production of proteins which, in turn, help smooth muscle cells relax.

Relaxing the smooth muscle in the penis allows it to fill with blood and achieve an erection.

Dr Geoff Hackett, president of the British Society for Sexual Medicine, said the gene therapy might be appealing to some men for whom other treatments had failed, but predicted many men would be reluctant to have a shot in the penis.

He stressed that many men with ED also had underlying medical disease, such as high blood pressure, raised cholesterol or diabetes, and that this should also be treated.

And there is a good argument for treating ED as a chronic disease too, he said.

“Maybe men with ED should be taking a pill for it every day. If you take smaller amounts regularly, the side-effects are less,” he explained.

US in tadalafil uk
found an increased risk in men with a history of heart attack or high blood pressure.

The University of Alabama team said healthcare professionals should warn patients of the potential risk.

The British Journal of Ophthalmology study follows several reports linking the drugs to eyesight problems.

NAION A common cause of sudden vision loss in people over 50 Caused by a blockage of the tiny ciliary arteries supplying blood to the anterior optic nerve There is no direct treatment, although corticosteroids are sometimes used to reduce swelling in the optic nerve

The findings are based on 76 men attending one US specialist eye clinic.

Half the men had optic nerve damage, diagnosed as cialis vs viagra
anterior ischaemic optic neuropathy (NAION), the rest were free of the problem.

All the patients were asked about their lifestyle, including smoking and alcohol intake, whether they had been diagnosed with heart disease, diabetes, or high blood pressure and prescribed treatment for these conditions.

They were also asked if they had been prescribed Viagra and Cialis for erectile difficulties.

Men with optic nerve damage were no more likely to have taken the impotency drugs than men in the comparison group.

But men who had had a heart attack were 10 times more likely to have optic nerve damage if they had taken Viagra or Cialis before their diagnosis.

Men with high blood pressure were also more likely to have optic nerve damage if they had taken these drugs, although this was not statistically online tadalafil kaufen
.

Blood flow

The authors caution that their study is small, but suggest that the drugs may reduce the blood flow to the anterior optic nerve, resulting in tissue damage.

They believe the drugs may heighten the risk of NAION in those with vascular disease, who are already more susceptible.

The researchers urge any patient who has endured a sudden severe loss of vision, and has been prescribed Viagra or Cialis, to contact a doctor.

Writing in the journal, they said: “Though NAION is a rare condition, the large number of men using Viagra or Cialis suggests that, should an association truly exist, the incidence of NAION could rise dramatically.”

An editorial in the same journal points out that some patients with impaired eyesight as a result of NAION have reportedly decided to sue Pfizer, the online tadalafil kaufen
of Viagra.

However, Pfizer has said there were no reports of NAION in the trials of the drug carried out before it was licensed.

The company also argued that a greater number of cases related to this type of drug would have been reported by now if the association was anything other than soft tablet tadalafil
.

Lilly ICOS, which manufactures Cialis, said there had been a small number of cases of NAION in people taking the drug.

This was now flagged up in the prescribing information.

In a statement, the company said it was difficult to establish a firm link as most patients taking impotency drug had other risk factors which rendered them potentially vulnerable to NAION.